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|Export Market:||Global||Packing Methods:||Designed Disguised Packing Ways, 100% Pass Custom Guarantee|
|Delivery Time:||3-7 Working Days||Delivery Method:||Ship By Express, Like EMS,DHL, Fedex, TNT, UPS, Aramex Etc|
|Shelf Life:||2years||Payment Methods:||T/T, Western Union, MoneyGram, Bitcoin|
99% Purity Antidote Raw White Powder Romazicon Flumazenil For Nootropic Supplement
1. Flumazenil Quick detail
|Packing Methods||foil bag or as your mind|
|Delivery time||within 18 hours after payment confirmed|
|Payment||T/T, Western Union,Money Gram , Bitcoin|
|Usage||Fumazenil is an imidazobenzodiazepine derivative.
Fumazenil a potent benzodiazepine receptor antagonist.
2. Fumazenil Description
Fumazenil is an imidazobenzodiazepine derivative and a potent benzodiazepine receptor antagonist that competitively inhibits the activity at the benzodiazepine recognition site on the GABA/benzodiazepine receptor complex, thereby reversing the effects of benzodiazepine on the central nervous system.
3. Flumazenil Half life
Initial distribution half-life is 4 to 11 minutes and the terminal half-life is 40 to 80 minutes. Prolongation of the half-life to 1.3 hours in patients with moderate hepatic impairment and 2.4 hours in severely impaired patients. Compared to adults, the elimination half-life in pediatric patients was more variable, averaging 40 minutes (range: 20 to 75 minutes).
Flumazenil is of benefit in patients who become excessively drowsy after benzodiazepines are used for either diagnostic or therapeutic procedures.
It has been used as an antidote in the treatment of benzodiazepine overdoses.It reverses the effects of benzodiazepines by competitive inhibition at the benzodiazepine binding site on the GABAA receptor. There are many complications that must be taken into consideration when used in the acute care setting.These include lowered seizure threshold, agitation, and anxiousness. Flumazenil's short half-life requires multiple doses and careful patient monitoring to prevent recurrence of overdose symptoms.
It is also sometimes used to reverse the effects of benzodiazepines after surgery in a manner similar to naloxone's application to reverse the effect of opiates and opioid following surgery. This requires careful monitoring by an anesthesiologist due to potential side effects and serious risks associated with both over-administering flumazenil and the removal of patient life-support and monitoring equipment before the benzodiazepines have worn off (due to flumazenil masking their continued effect).
Flumazenil has been effectively used to treat overdoses of non-benzodiazepine hypnotics, such as zol-pidem,.
It may also be effective in reducing excessive daytime sleepiness while improving vigilance in primary hypersomnias, such as idiopathic hypersomnia.
It has also been used in hepatic encephalopathy, though results have been mixed.
The onset of action is rapid and usually effects are seen within one to two minutes. The peak effect is seen at six to ten minutes. The recommended dose for adults is 200 μg every 1-2 minutes until the effect is seen, to a maximum of 3 mg per hour. It is available as a clear, colourless solution for intravenous injection, containing 500 μg in 5 mL.
5. Flumazenil Specification
|Items of analysis||Specification||Results|
|Appearance||White crystalline powder||White Crystalline Powder|
|Identification||The sample'S IR spectrum is according with spectrum of Flumazenil,The retention time of the major peak Flumazenil in the chromatogram of the Assay preparation corresponds to that in the chromatogram of the Standard preparation||Conforms|
|Melting point||198ºC to 202ºC||200.6ºC to 200.9ºC|
|Appearance of solution||The solution is clear and is not Intenser than reference solution BY7||Conforms|
|Impurity C||NMT 0.2%||0.02%|
|Impurity A||NMT 0.10%||Not detected|
|Impurity B||NMT 0.2%||0.03%|
|Impurity D||NMT 0.10%||0.03%|
|Impurity E||NMT 0.10%||Not detected|
|Impurity F||NMT 0.10%||Not detected|
|Individual unknown impurituy||NMT 0.10%||0.02%|
|Total impurities||NMT 0.5%||0.1%|
|Loss on drying||NMT 0.5%||0.2%|
|Sulphated ash||NMT 0.1%||0.05%|
|Heavy metals||≤0.5 ppm||5ppm|
|Microbial limits( for Injection)||Bacteria not more than 50CFU/g||<10 CFU/g|
|Microbial limits||Mildew and microzyme not more than 50CFU/g||<10 CFU/g|
|Microbial limits||Escherichia coli absence||Absence|
|Acetic acid||NMT4000ppm||Not detected|
|Assay (On dried substance)||98.0-102.0%||99.80%|
|Bacterial endotoxins||not more than 25.0 USP Endotoxin Units per mg of flumazenil.||not more than 8.0 USP Endotoxin Units per mg of flumazenil.|
|Guarantees the nature time||36 months||36 months|
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