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PCT Clomid Antiestrogen Raw Powder Clomifene Citrate CAS No: 50-41-9 Asaromatase Inhibitors
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Key words:Clomifene citrate,Clomifene citrate,Clomifene,Clomifene,Clomid,Clomid,Clomid,Anti-estrogen Raw
Clomid (clomiphene) is a non-steroidal fertility medicine. It causes the pituitary gland to release hormones needed to stimulate ovulation (the release of an egg from the ovary).
Clomid is used to cause ovulation in women with certain medical conditions (such as polycystic ovary syndrome) that prevent naturally occurring ovulation.
Clomid may also be used for purposes not listed in this medication guide.
Clomid is a mixed estrogen agonist/antagonist (activator/blocker) which, when bound to the estrogen receptor, puts it in a somewhat different conformation (shape) than does estradiol. The estrogen receptor requires binding of an estrogen or drug at its binding site and also the binding of any of several cofactors at different sites. Without the binding of the cofactor, the estrogen receptor is inactive. Different tissues use different cofactors. Some of these cofactors are able to bind to the estrogen receptor/Clomid complex, but others are blocked due to the change in shape. The result is that in some tissues Clomid acts as an antagonist - the cofactor used in that tissue cannot bind and so the receptor remains inactive - and in others Clomid acts as an agonist (activator), because the cofactors used in that tissue are able to bind.
Clomifene citrate (Clomid) Basic info.
Synonyms: Clomid; Clomiphene citrate
Another name:2-4-[2-Chloro-1,2-diphenylethenyl]phenoxy-N,N-diethylethanamine citrate
CAS NO: 50-41-9
Einecs No: 200-035-3
Appearance: white or milky white crystalline powder
Use: the goods to anti-estrogen fertility inducer, the objects in dysfunctional uterine bleeding, polycystic ovary, menstrual disorders and drug-induced amenorrhea and other gynecologic diseases
Steroids Hormone Clomiphene Citrate/Clomid powders/CAS No: 50-41-9
Clomid is the anti-estrogen of choice for improving recovery of natural testosterone production after a cycle, improving testosterone production of endurance athletes, and is also effective in reducing risk of gynecomastia during a cycle employing aromatizable steroids.
Along with Nolvadex, Clomid is one of the two principal SERMs (selective estrogen receptor modulators) used for enhanced recovery of testosterone production after anabolic steroid cycles.
To understand how Clomid can aid this process, let’s look at how natural testosterone production is regulated.
Testosterone production is regulated by a feedback loop which senses not only testosterone or other androgen levels, but also estrogen levels. This feedback loop includes the hypothalamus, the pituitary, and the testes (often referred to as the HPTA, or hypothalamic-pituitary-testicular axis.)
When the hypothalamus senses low estrogen levels and does not sense high androgen levels, it’s stimulated to signal the pituitary by producing more LHRH, which stands for LH releasing hormone. On receiving this signal, the pituitary produces more LH (luteinizing hormone) which in turn signals the testes to produce more testosterone.
During an anabolic steroid cycle, high androgen levels shut this process down entirely. If this is for only a relatively short period such as 8 weeks, this is not a real issue. Over a longer period of time, testicular atrophy might occur, however. That can be avoided with HCG usage. Something that cannot be avoided, however, is that the hypothalamus and pituitary respond not only according to the hormone levels which they sense at a given moment, but are affected in their response by their recent exposure. When that exposure has been an extended period of anabolic steroid use, responsiveness typically is poor even after anabolic steroid use has ceased.
Clomid, as does Nolvadex, works by occupying the binding sites of estrogen receptors of cells, without activating the receptors. This reduces the extent to which estradiol can activate these receptors. In the case of the hypothalamus, this leads to the hypothalamus “concluding” that estrogen levels are low. If androgen levels are not elevated, as indeed they should not be after an anabolic steroid cycle, the hypothalamus is then stimulated to produce LHRH. This will act to increase LH and restart natural testosterone production.
Clomid ordinarily is dosed at 50 mg/day. However, it’s important to note that clomiphene has a long half life. Where this has relevance is that when a daily dose is taken, the body will have not only that dose in it, but also an accumulated amount of about five days’ worth of previous doses as well. That’s fine: it results in correct blood levels. Where there can be a problem is when first starting use. If simply taking 50 mg/day from the beginning, there is no such buildup and levels will be low.
To account for this, 300 mg is taken on the first day, as three doses of 100 mg, or optionally six doses of 50 mg. This immediately gets levels to where they should be. Ongoing 50 mg/day dosing will maintain this level.
After day 1, doses of more than 50 mg are not needed and are not recommended. They will not improve results, but may increase adverse side effects.
Adverse side effects of Clomid can include increased emotionalism or vision disturbance. If vision disturbance is experienced, Clomid should be discontinued immediately.
Clomid rarely leads to libido issues, which can be a problem with Nolvadex. For this reason some prefer it to Nolvadex. Others, who do not have that issue with Nolvadex, may prefer that drug. Both are effective for restoring natural testosterone production. I have a slightly better opinion of Clomid for effectiveness, but where a person dislikes Clomid for emotional effects, or prefers Nolvadex for any reason, Nolvadex is a perfectly acceptable substitute.
Clomid VS Nolvadex
Clomid differs from Nolvadex in that while SERMs are always anti-estrogenic in some tissues, they are estrogenic in others. Fortunately, both Clomid and Nolvadex are anti-estrogenic in the hypothalamus, making them useful for post-cycle therapy (PCT), and anti-estrogenic in breast tissue, making them useful as anti-gyno agents. Clomid however is estrogenic in the pituitary, which in some instances may even enhance its value for PCT. It’s likely estrogenic to at least some other neurons in the brain as well, causing increased emotionality. With regard to body fat and muscle, or any observable physical property, Clomid and Nolvadex have no other adverse estrogenic effects, but instead are useful anti-estrogens.
PCT with Clomid should begin as soon as androgen levels have dropped to normal, and continue until confident that natural testosterone production has been fully restored.
Clomid, properly, is a brand name: typically clomiphene citrate products are used, but popularly called Clomid. Clomiphene citrate is widely available both as a pharmaceutical and even more widely as a research chemical, often in liquid form for oral use.
Clomid can and usually should be used as the only SERM in PCT. In most instances, there is no point to combining with another SERM. Where a second SERM such as Nolvadex is combined with Clomid, each should be used at half dose rather than full dose. Using full dose of each does not provide enhanced efficacy and only increases risk of side effects.
Clomiphene citrate is the chemical name of active ingredient in Clomid. Clomid is a registered trademark of Merrell Dow Pharmaceuticals in the United States and/or other countries.
Clomid (clomiphene citrate) and post cycle therapy (PCT)
Question: When do I start Clomid?
Answer: When you start using your clomid all depends on what steroids you were using during your cycle. Different steroids have different half lifes and you should adjust your clomid intake accordingly. As we have seen above, if we take clomid when the androgen levels in our body is still high it will be a waste. We need to wait for androgen levels to fall before implementing our clomid therapy. However if we take it too late we could possibly lose gains. Look at the list below to determine when you should start clomid therapy. By selecting from the list all the steroids you used in your cycle and which ever one has the latest starting point then go with that. For example if I cycled dbol, sustanon and winstrol I would use sustanon as it remains active in the body for the longest period of time.
Anadrol/Anapolan: 8 - 12 hours after last administration
Deca: 3 weeks after last injection and clomid for 4 weeks
Dianabol: 4 - 8 hours after last administration
Equipoise: 3 weeks after last injection
Fina: 3 days after last injection
Primobolan depot: 10 - 14 days after last injection
Sustanon: 3 weeks after last injection
Testosterone Cypionate: 2 weeks after last injection
Testosterone Enanthate: 2 weeks after last injection
Testosterone Propionate: 3 days after last injection
Testosterone Suspension: 4 - 8 hours after last administration
Winstrol: 8 - 12 hours after last administration
Question: What is the most effective way for Clomid therapy.
Answer: Clomid has a long half life and as such there is no need to split up doses throughout the day. I read some where that it was 5 days (any feedback on this). Now if we used sustanon and we start using clomid 3 weeks after our last injection we anticipate that androgen levels are low enough to start sending the correct signals. If androgen levels are still a little high then the normal 50mgs/day of clomid for 1 week is not going to be effective. We need to start at a high enough amount that will work or help even if androgen levels are still a little high. 300mgs on day 1. I know I said don’t split it up due to its long half life but try and split this up 2 tabs 3 times a day. After we have finished this first day we seek to use 100mgs for 10 days and then followed by 50mgs for 10 days.
Question: Do I need to use Clomid for 3 weeks?
Answer: Why don’t you want too? It is very cheap, very effective and can mean the difference between maintaining gains and losing them.
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