Boldenone Anabolic Steroid Powder Boldenone Base CAS 846-48-0 For Good Body Shape Big Mass
Boldenone can be converted to estrogen but less so than testosterone, in addition, boldenone is metabolized to 1,4 dienedione which is a potent aromatase inhibitor. Boldenone is converted by 5-alpha reductase to 1-testosterone, a more potent steroid as well as to the 5-beta isomer which is thought to be an inactive metabolite. Binding to SHBG is much lower with boldenone than with testosterone meaning a larger free plasma concentration but a shorter half-life in plasma. There is little to no binding to progesterone or glucocorticoid receptors and no real data on the interaction of boldenone with the different enzyme systems.
Boldenone acts similar to methandrostenolone with less adverse androgenic effects. It has a very long half-life, and can show up on a steroid test for up to 5 months, due to the long undecylenate ester attached to the parent steroid. Trace amounts of the drug can easily be detected for months after discontinued use.
Although commonly compared to nandrolone, boldenone lacks progesterone receptor interaction and all the associated progestogenic side effects.
Mechanism of action
Boldenone is a steroid hormone which has androgenic activity. Androgens bind to the androgen receptor, which regulates gene transcription.
Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins.
Controlled substance. Anabolic steroid. Is a male hormone, anabolic hormones drugs.Although anabolic androgenic steroids like Boldenone may increase lean muscle mass, strength, and the ability to train longer and harder, the serious side effects of steroids are many and may not be reversible.
The minor side effects of steroid use include acne, oily skin, excess hair growth, and deepening of the voice. At higher doses ofboldenone, users can expect to reap better results than previously suggested cycles of 400mg/week or lower.
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Boldenone Base Use in sports
Boldenone is among the substances banned by Major League Baseball, as well as most other major athletic organizations. Los Angeles Angels minor league outfielder Reynaldo Ruiz in September 2010 and Philadelphia Phillies minor league pitcher San Lazaro Solano in January 2011 each received a 50-game suspension for the 2011 season as a result of testing positive for a metabolite of boldenone. Jenrry Mejia, formerly of the New York Mets, was suspended in July 2015 when he tested positive for boldenone and stanozolol, and in February 2016 he again tested positive for boldenone; this marked Mejia's third positive test for a performance-enhancing drug, for which he received the first PED-related lifetime ban in MLB history. Abraham Almonte was suspended for 80 games before the 2016 season after testing positive for boldenone.
2. Mixed martial arts
Stephan Bonnar and Josh Barnett, mixed martial arts (MMA) fighters from the UFC and PRIDE Fighting Championships, have also tested positive for the banned substance. After the World Extreme Cagefighting show on January 20, 2006 Muay Thai turned MMA fighter Kit Cope also tested positive for boldenone. Following the Strikeforce card on June 22, 2007 former PRIDE and UFC fighter Phil Baroni tested positive for boldenone, as well as stanozolol. At a K-1 WGP event in Las Vegas on August 17, 2007 two fighters, Rickard Nordstrand and Zabit Samedov, both tested positive for boldenone. Alexandre Franca Nogueira tested positive for boldenone in July 2008.
Antonio Silva tested positive for boldenone after his July 26, 2008 fight against Justin Eilers in the EliteXC promotion. Silva was suspended by the California State Athletic Commission for a year and fined $2500.
3. Horse racing
Leading horse trainer Gai Waterhouse was fined $10,000 after being found guilty on May 15, 2008 of presenting a horse to the races with a prohibited substance in its system. Her horse Perfectly Poised was found to have traces of the banned substance boldenone in its system after finishing second at Canterbury in April 2007.
Boldenon displays a weaker binding affinity for the androgen receptor than testosterone, yet it is less prone to attach to sex hormone binding globulin, which likely helps to balance out its myotropic effects. The drug will maintain blood levels of the base compound for roughly 14-16 days post-injection, yet twice weekly injections are appropriate when attempting to maintain stable blood levels.
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