CAS 140703-51-1 Hexarelin Protein Peptide Hormones 2mg/Vial 5mg/Vial For Bodybuilding

Basic Information:

Single Impurity (HPLC): 0.5%max
Amino Acid Composition: about10% of theoretical
Peptide Content (N%): 80.0%min.
Water Content(Karl Fischer): 8.0%max.
Acetate Content(HPIC): 10.0%max.
Specific Rotation (20/D): -55.0~-65.0 degree(c=1 1%HAc)
MS(ESI): Consistent
Mass Balance: 95.0~105.0%
Appearance: White powder
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Description:

PT-141, also called as Bremelanotide, is a derivative for Melanotan 2 (M2). Unlike M2, PT-141 lacks C-terminal amide molecules. Bremelanotide is a cyclic hepta-peptide lactam derivative of alpha-MSH. PT-141 acts by stimulating melanocortin receptors present in the central nervous system. Due to this potential, PT-141 is being studied as a potential treatment for sexual disorders such as erectile disorders in men and sexual arousal disorders in women.The amino acid structure of PT-141 is Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-OH or cyclo-[Nle4, Asp5, D-Phe7, Lys10]alpha-MSH-(4-10). It is not a vasoactive compound, rather acts directly in the higher centers to increase sexual activity.

Hexarelin is a six-amino acid peptide. Studies have shown that hexarelin is actually more effective and longer lasting than growth hormone releasing hormone (GHRH). It is also known that GHRP-6 has a synergistic effect with GHRH, causing a far greater release than either of these substances alone. By combining GHRP-6 with Hexarelin, a more potent GH releasing peptide combination is created than ever heard of. The potential clinical usefulness of these GH releasing hexapeptides is also reinforced by observations that long-term administration produces elevations in circulating IGF-1 concentrations. Long term treatment with GHRP-6 similarly has been shown to elevate serum IGF-1 as well as IGF-binding protein-3 concentrations and promote linear growth.

Application:

1. Ghrelin is an appetite-regulating factor secreted from peripheral organs that is involved in regulation of energy homoeostasis via binding to the receptor resulting in the secretion of growth hormone by the pituitary gland. The pathway activated by binding of ghrelin to the growth hormone secretagogue receptor, GHSR1a, regulates the activation of the downstream mitogen-activated protein kinase, Akt, nitric oxide synthase, and AMPK cascades in different cellular systems. One of the important features of

2. GHSR1a displays constitutive activity possessing basal activity in the absence of an agonist, resulting in a high degree of receptor internalization as well as of signaling activity.Inverse agonists for the ghrelin receptor could be particularly interesting for the treatment of obesity.This activity seems to provide a tonic signal required for the development of normal height, probably through an effect on the GH axis.

The benefits of Hexarelin:

• The strongest pulse from a GHRP.
• Increase LBM (lean body mass).
• Help with fat reduction.
• Increase bone density.
• Anti aging properties heals skin.
• Heart protective properties shown to heal heart tissue.

Benefits:

Interestingly, the most amazing finding with hexarelin was its ability to act on cardiac receptors separate from the GH releasing properties. The peptide can directly aid in cardio protective left ventricular pressure issues, as well as, help healing scar tissue on the heart. Studies on lean and obese lab rats concluded that while lean rats were able to take advantage of the GH plasma increase better than the obese rats (the healthier the rat the more hexarelin effectively produced and utilized GH), obese rats did not see the same advantage. Separate from the studies that monitored GH, both lean and obese rats both received all of the cardio protective properties of hexarelin.

Dosage and Usage:

Hexarelin comes in a freeze dried powder just like the other GHRP peptides and storage should be done in a cool dry place until reconstituted and placed in a refrigerator. Bacteriostatic water is used to reconstitute the powder and an insulin syringe is the preferred method for administering subcutaneous injections of hexarelin. Users will notice 200mcgs is the saturation dose for hexarelin and over a few weeks of use total desensitization may begin to take place. Also, the occasional flare up of the pituitary has been noted when dosing far beyond saturation doses. Desensitization can be cleared easily by taking a break from hexerlin usage for a few days to a few weeks. This GHRP is the strongest, and because of the desensitization factor, I believe the optimal way to use this peptide would be to blend it at low doses with other GHRP’s like GHRP2, GHRP6 or iPamorelin. By combining a low dose of hexearelin with another GHRP, you are going to increase your ability to put out a greater pulse of growth hormone. Combine this with GHRH’s and you have a synergistic blend that will release GH more effectively. In fact, for synthetic HGH users, this may be a viable way to save money on using less exogenous GH by combining it with hexarelin in a GHRP+GHRH cycle. As a result, utilizing hexarelin in this protocol would establish the maximum GH release in the body.

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