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|State::||Solid||Appearence::||Off-White Cyrstalline Powder|
CAS 129938-20-1 Male Enhancement Raw Steroids Powder Hydrochloride
Synonyms: d- hydrochloride; DL- hydrochloride
CAS No.: 129938-20-1
Assay: 98% min.
Packing: 1kg net/foil bag or tin.
Delivery: Express courier.
Character: White to Off-White Cyrstalline Solid, odorless, slight sweet taste, Mp 175-177℃, optical rotation +128°
Related Product List:
|Related Product list:|
|product name||CAS MO.|
|9||Testosterone enanthate(primoteston )||315-37-7|
|36||Methenolone enanthate (Primo E)||303-42-4|
1. We have experience in exporting steroids, as you know, EU places much emphasis on them, and you must find a experienced partner who will assure you;
2. Quality: Our company is a professional leading factory in China in pharmaceutical area, We had stable customers and exported to Germany, Spain, UK, USA, Australia, Middle East, and any other countries. We can provide good references about our company. As for the quality of the products, we 're sure they can satisfy you well enough;
3. Package: Professional packing with professional materials
4. Delivery: We have products in stock, and we will deliver them soon when your PO arrived. Meanwhile we will give you the tracking number in order to make you know the exact location of the products. We will keep track of the product until they arrive you; We choose the best courier service for you, and with the delivery around 4-7 working days.
5. Service: Best Service with after-sales service and consultation.
Related Product list:
6. We are the manufacturer of all kinds of hormone powders. We focus on providing customers with high quality products, competitive price, best service and timely delivery.
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8. Payment methods:Western Union,MoneyGram We will supply the receiver’s information or the bank account information for payment use.
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10. Please kindly supply the shipping address, contact and tel number for successful shipment.We are 100% confident of my shipment method.
A contraindication is a situation in which a drug should not be used, because it may be harmful to the patient. should not be used in men with moderate to severe hepatic impairment and in those receiving CYP3A4 inhibitors such as ketoconazole, ritonavir, and telithromycine. can also not be used in patients with heart failure, permanent pacemaker, or other significant ischemic heart disease. Caution is advised in men receiving thioridazine, monoamine oxidase inhibitors, SSRIs, serotonin-norepinephrine reuptake inhibitors, or tricyclic antidepressant. If a patient stops taking one of these drugs, he should wait for 14 days before taking . If a patient stops taking , he should wait for 7 days before receiving these drugs.
The most common effects when taking are nausea, dizziness, dry mouth, headache, diarrhea, and insomnia.Discontinuation due to adverse effects is dose related. According to McMahon in recent study in Asia, the rate of discontinuation is 0.3%, 1.7%, and 5.3% of 1067 studied subjects with placebo, 30 mg, and 60 mg respectively. Unlike other SSRIs used to treat depression, which have been associated with high incidences of sexual dysfunction, is associated with low rates of sexual dysfunction. Taken as needed, has very mild adverse effects on loss of libido (<1%) and ED (<4%).
No case of the drug overdose has been reported during clinical trials.
With phosphodiesterase inhibitors (PDE5 inhibitors)
Many men that have PE also suffer from erectile dysfunction (ED). Treatment for these patients should consider the drug-drug interaction between and PDE5 inhibitors such as tadalafil (Cialis) or sildenafil (Viagra). In Dresser study (2006), plasma concentration of 24 subjects was obtained. Half of the sample pool were treated with 60 mg + tadalafil 20 mg; the other half were treated with 60 mg + sildenafil 100 mg. These plasma samples were then analyzed using liquid chromatography-tandem mass spectrometry. The results showed that does not alter the pharmacokinetic of tadalafil or sildenafil.
Ethanol doesn't affect the pharmacokinetics of when taking concurrently with .
Mechanism of actions
The mechanism through which affects premature ejaculation is still unclear. However, it is presumed that works by inhibiting serotonin transporter and subsequently increasing serotonin's action at pre and postsynaptic receptors Human ejaculation is regulated by various areas in the central nervous system (CNS). The ejaculatory pathway originates from spinal reflex at the thoracolumbar and lumbosacral level of spinal cord activated by stimuli from male genital. These signals are relayed to the brain stem, which then is influenced by a number of nuclei in the brain such as medial preoptic and paraventricular nulcei. Clement's study performed on anaesthetized male rats showed that acute administration of inhibits ejaculatory expulsion reflex at supraspinal level by modulating activity of lateral paragigantocellular nucleus (LPGi) neurons. These effects cause an increase in pudendal motoneuron reflex discharge (PMRD) latency. However, it is unclear whether acts directly on LPGi or on the descending pathway in which LPGi located.
is a white powder substance and water- insoluble. Taken 1-3 hours before sexual activity, it is rapidly absorbed in the body. Its maximum plasma concentration (Cm) is reached 1-2 hours after oral administration. The Cm and AUC (Area Under the plasma vs. time Curve) are dose dependent. The Cm and Tm (time needed to obtain the maximum plasma concentration) after single doses of 30 mg and 60 mg are 297 and 498 ng/mL at 1.01 and 1.27 hours respectively. A high fat meal does reduce the Cm slightly, but it is insignificant. In fact, food doesn’t alter pharmacokinetics. can be taken with or without food.
is absorbed and distributed rapidly in the body. Greater than 99% of is bound to the plasma protein. The mean steady state volume is 162L. Its initial half-life is 1.31hours (30 mg dose) and 1.42 hours (60 mg dose,) and its terminal half life is 18.7 hours (30 mg dose) and 21.9 hours (60 mg dose).
is metabolized extensively in the liver and kidney by multiple enzymes such as CyP2D6, CyP3A4, and flavin monooxygenase 1 (FMO1). The major product at the end of the metabolic pathway is circulating N- oxide, which is a weak SSRI and contributes no clinical effect. The other products presented less than 3% in the plasma are desmethyl and didesmethy, which are equipotent to .
The metabolites of are eliminated rapidly in the urine with a terminal half-life of 18.7 and 21.9 hours for a single dose of 30 mg and 60 mg respectively.
Safety and tolerability
The cardiovascular safety profile of has been studied extensively during the drug development. Phase I trials showed that had neither clinical significant electrocardiographic effects nor delayed repolarization effects, with dosing up to 4-fold greater than the maximum recommended dosage which is 60 mg. Phase III studies in men with PE showed a safety and well tolerate profile of with dosing of 30 and 60 mg. There is no cardiovascular adverse had been found.
|Appearance||White or almost white crystalline powder||Complies|
|Loss on drying||≤2.0%||0.5%|
|Melting Point||175°Cto 185°C||180°C|
|A. Single impurity||≤0.2%||Complies|
|B. Total impurities||≤0.5%||0.3%|
|Assay||98.0% to 102.0%||99.2%|
|Conclusion: Conform to the Enterprise standard|
Feedback from customers :
I am very satisfied with all. Yesterday I made the testosterone enanthat in a solution with oil. The solution is completely claer, it is a good powder
--Karl. From Australia
Hi Janney, I want you to know that I am satisfied and even somewhat excited. I knew when I received the last package that you are a real professional and I really was comforted seeing how well you packaged these items.
Hi Janney, I am very pleased with your products and services and will continue to give my business to you exclusively for all powders. I will be placing an order very soon as I am completely out of stanozolol which is pretty popular.
I will be in touch soon. I just need to get my finances in order.
--Jeff From Brazil
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