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Pharma Sarms Powder MK-1775 Inhibits Wee1 Kinase CAS no 955365-80-7

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Pharma Sarms Powder MK-1775 Inhibits Wee1 Kinase CAS no 955365-80-7

China Pharma Sarms Powder MK-1775 Inhibits Wee1 Kinase CAS no 955365-80-7 supplier
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Product Details:

Place of Origin: China
Brand Name: HKYC
Certification: ISO 9000, SGS
Model Number: sarms powder

Payment & Shipping Terms:

Minimum Order Quantity: 10grams
Price: negotiable(best offer will be provided)
Packaging Details: designed disguised packing ways, 100% pass custom guarantee)
Delivery Time: within 24hours after payment confirm
Payment Terms: MoneyGram, Western Union, T/T, Bitcoin
Supply Ability: 1000Kg per Month
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Detailed Product Description
Product Name: MK-1775 Purity: 99%min
Packaging: Safety And Discreet PKG Delivery: Special Disguised Package Or Customized Guarantee 100% Custom Pass Rate
Courier: EMS, HKEMS, FedEx, TNT, DHL Payment: MoneyGram, Western Union, T/T,
COA Result: Available Fuction: MALE SEX ENHANCER
MOQ: 10g User: Adult

Pharma Sarms Powder MK-1775 Inhibits Wee1 Kinase CAS: 955365-80-7

 

 

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Product Name: MK-1775
Product Name: 2-allyl-1-(6-(2-hydroxypropan-2-yl)pyridin-2-yl)-6-(4-(4-methylpiperazin-1-yl)phenylamino)-1H-pyrazolo[3,4-d]pyrimidin-3(2H)-one
Synonyms: 2-allyl-1-(6-(2-hydroxypropan-2-yl)pyridin-2-yl)-6-(4-(4-methylpiperazin-1-yl)phenylamino)-1H-pyrazolo[3,4-d]pyrimidin-3(2H)-one;MK-1775;MK-1775,MK1775;2-allyl-1-(6-(2-hydroxypropan-2-yl)pyridin-2-yl)-6-(4-(4-methylpiperazin-1-yl)phenylamino)-1,2-dihydropyrazolo[3,4-d]pyrimidin-3-one;2-Allyl-1-(6-(2-hydroxypropan-2-yl)pyridin-2-yl)-6-(4-(4-methylpiperazin-1-yl)phenylamino)-1H-pyrazolo[3,4-d]pyrimidin-3(2H)-one MK 1775;MK 1775 2-Allyl-1-(6-(2-hydroxypropan-2-yl)pyridin-2-yl)-6-(4-(4-methylpiperazin-1-yl)phenylamino)-1H-pyrazolo[3,4-d]pyrimidin-3(2H)-one;MK-1775, >=98%;MK-1175
CAS: 955365-80-7
MF: C27H32N8O2
MW: 500.59538

 

Detailed Descriptions of Mk-1775


Synonyms AZD 1775
MK-1775 is an inhibitor of the checkpoint kinase Wee1 (IC50 = 5.2 nM).1 It has been shown to inhibit the phosphorylation of Cdc2 at
tryosine-15, which abrogates the G2 DNA damage checkpoint.1 In p53-deficient tumors that rely solely on the G2 checkpoint upon DNA
damage, MK-1775, in combination with DNA-damaging chemotherapeutic agents, is reported to induce apoptosis in vitro and potentiate

MK-1775 inhibits Wee1 kinase in an ATP-competitive manner. Compared to Wee1, MK-1775 displays 2- to 3-fold less potency against Yes with IC50 of 14 nM, 10-fold less potency against seven other kinases with >80% inhibition at 1 μM, and >100-fold selectivity over human Myt 1, another kinase that inhibits cyclin-dependent kinase 1 (CDC2) by phosphorylation at an alternative site (Thr14). By abrogating the DNA damage checkpoint via blockade of Wee1 activity in WiDr cells bearing mutated p53, MK-1775 treatment inhibits the basal phosphorylation of CDC2 at Tyr15 (CDC2Y15) with EC50 of 49 nM, and suppresses gemcitabine-, carboplatin- or cisplatin-induced phosphorylation of CDC2 and cell cycle arrest in a dose-dependent manner, with EC50 of 82 nM and 81 nM, 180 nM and 163 nM, as well as 159 nM and 160 nM, respectively. MK-1775 treatment alone at 30-100 nM has no significant antiproliferative effect in WiDr and H1299 cells, whereas MK-1775 at 300 nM, sufficient to inhibit Wee1 by >80%, displays moderate but significant antiproliferative effects by 34.1% in WiDr cells and 28.4% in H1299 cells.


in vivo: MK-1775 treatment alone at ~20 mg/kg displays minimal antitumor effects against WiDr xenografts in rats with T/C of 69% at day 3. Antitumor efficacy by MK-1775 alone in the nude rat HeLa-luc and TOV21G-shp53 xenograft models models is also moderate.

 

 

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ABOUT US
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We're specialized in pharma.raw materials ( hormone steroid powders, Steroids injectable liquids,peptides,Sarms), our company integrates R&D, producing, operating and marketing into an organic whole. We have authority of export and import, and have experience of export for 15 years.

Major Market: United States, United Kingdom, Australia, Canada, Sweden, Russia, Poland, Brazil, Israel, Netherlands, Germany,Spain, Switzerland, Poland and so on.

MOQ:10g

Package:Disguised & Discreet pkg
Payment:T/T,Western Union,Moneygram,bitcoin
Delivery: sent out the goods within 24hours after receiving payment.
Custom Pass rate:99%
Resend policy is available if the parcle is seized or any quality problems been found.


After-sale Service :
Discounts are available for our second-time customers. We can provide recipes and professional suggestions to promote yourselves. Tracking number and packing photos can be given quickly after your goods sent. We are always here waiting for you!

 

 

 

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Pharma Sarms Powder MK-1775 Inhibits Wee1 Kinase CAS no 955365-80-7

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