Steroidal Progestin Chlormadinone Acetate / CMA For Antiestrogenic And Antigonadotropic CAS 302-22-7
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Chlormadinone Acetate Spec.
Product Name: Chlormadinone acetate
CAS NO.: 302-22-7
Molecular Formula: C23H29ClO4
Molecular Weight: 404.93
Delivery: in 24 hours after payment.
The min. order:10 grams.
Appearance: White powder
Chlormadinone Acetate Description:
Chlormadinone acetate (CMA) is a derivative of progesterone (17α-acetoxy-6-chloro-4,6-pregnadiene-3,20-dione).
Chlormadinone acetate has a strong progestogenic effect - about one-third higher than that of progesterone - and may vary depending on the previous effect of an estrogen, i.e., estrogens may promote the formation of progesterone receptors and proliferation of the endometrium. Like progesterone, it is anti-estrogenic and has no partial androgenic effect (at the doses used for contraception and HRT). In contrast to progesterone, it has a slight glucocorticoid effect, a pronounced anti-androgenic effect and no anti-mineralocorticoid effect. No pregnancy-maintaining effect of CMA has been demonstrated in humans.
Description and Application :
Chlormadinone acetate is a steroidal progestin with additional antiandrogen and antigonadotropic (and thus also antiestrogenic) effects. It is used clinically as a hormonal contraceptive, and in part due to its lowering of estrogen levels, but also for improved effectiveness in contraception, chlormadinone is frequently combinedwith ethinyl estradiol for this purpose.
Chlormadinone acetate has a strong anti-gonadotropic effect, through negative feedback on gonadotropin secretion, and has been used for more than 20 years alone for contraception in arterial risk patients. The clinical and metabolic tolerability of CMA has been demonstrated in numerous clinical studies with duration of treatment of up to 2.5 years.
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